Zürich BioGenix
MOTS-C · 10mg
MOTS-C · 10mg
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✓ HPLC Purity >99% ✓ COA on Every Batch ✓ Cold Chain Maintained ✓ EU Compliant
MOTS-C is a 16-amino acid mitochondrial-derived peptide (MDP) encoded within the 12S rRNA region of the mitochondrial genome. It acts as a metabolic regulator that translocates to the nucleus under metabolic stress, where it activates AMPK and the FOXO pathway to improve insulin sensitivity, fatty acid oxidation, and skeletal muscle glucose uptake. MOTS-C has been studied in the context of exercise mimetics, longevity signalling, age-related metabolic decline, and mitochondrial biology.
Synthesised and lyophilised in Zürich to >99% HPLC purity. Lot-traceable with full COA available upon request.
Technical Specifications
| Chemical Name | MOTS-C (Mitochondrial ORF of 12S rRNA type-C) |
| CAS Number | 1627580-64-6 |
| Molecular Formula | C101H152N28O22S2 |
| Molecular Weight | 2174.53 g/mol |
| Sequence | Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg (16 AA) |
| Purity | >99% (HPLC-UV) |
| Form | Lyophilised Powder |
| Storage | -20C, protect from light and moisture |
| Reconstitution | Bacteriostatic water or sterile saline |
Research & Literature
MOTS-C was first characterised by Lee et al. (2015) in Cell Metabolism as a novel mitochondria-derived peptide encoded by the 12S rRNA region of the mitochondrial genome. Research has demonstrated its role in regulating insulin sensitivity, skeletal muscle glucose uptake, and adipogenesis through AMPK activation and FOXO pathway modulation. Studies in aged mice showed that systemic MOTS-C administration restored youthful metabolic homeostasis and improved exercise capacity, suggesting a role in longevity signalling.
For research purposes only. Not for human consumption. Supplied in accordance with EU Regulation (EC) No 1907/2006 (REACH) for research and analytical use.
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