{"product_id":"mots-c-10mg","title":"MOTS-C · 10mg","description":"\u003cp\u003e\u003cstrong\u003eMOTS-C\u003c\/strong\u003e is a 16-amino acid mitochondrial-derived peptide (MDP) encoded within the 12S rRNA region of the mitochondrial genome. It acts as a metabolic regulator that translocates to the nucleus under metabolic stress, where it activates AMPK and the FOXO pathway to improve insulin sensitivity, fatty acid oxidation, and skeletal muscle glucose uptake. MOTS-C has been studied in the context of exercise mimetics, longevity signalling, age-related metabolic decline, and mitochondrial biology.\u003c\/p\u003e\u003cp\u003eSynthesised and lyophilised in Zürich to \u0026gt;99% HPLC purity. Lot-traceable with full COA available upon request.\u003c\/p\u003e\u003cdetails\u003e\u003csummary\u003e\u003cstrong\u003eTechnical Specifications\u003c\/strong\u003e\u003c\/summary\u003e\u003ctable\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eChemical Name\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eMOTS-C (Mitochondrial ORF of 12S rRNA type-C)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eCAS Number\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e1627580-64-6\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eMolecular Formula\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eC101H152N28O22S2\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eMolecular Weight\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e2174.53 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eSequence\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eMet-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg (16 AA)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003ePurity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u0026gt;99% (HPLC-UV)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eForm\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eLyophilised Powder\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eStorage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e-20C, protect from light and moisture\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eReconstitution\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eBacteriostatic water or sterile saline\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e\u003c\/details\u003e\u003cdetails\u003e\u003csummary\u003e\u003cstrong\u003eResearch \u0026amp; Literature\u003c\/strong\u003e\u003c\/summary\u003e\u003cp\u003eMOTS-C was first characterised by Lee et al. (2015) in Cell Metabolism as a novel mitochondria-derived peptide encoded by the 12S rRNA region of the mitochondrial genome. Research has demonstrated its role in regulating insulin sensitivity, skeletal muscle glucose uptake, and adipogenesis through AMPK activation and FOXO pathway modulation. Studies in aged mice showed that systemic MOTS-C administration restored youthful metabolic homeostasis and improved exercise capacity, suggesting a role in longevity signalling.\u003c\/p\u003e\u003c\/details\u003e\u003cp\u003e\u003cem\u003eFor research purposes only. Not for human consumption. Supplied in accordance with EU Regulation (EC) No 1907\/2006 (REACH) for research and analytical use.\u003c\/em\u003e\u003c\/p\u003e","brand":"Zürich BioGenix","offers":[{"title":"Default","offer_id":53670369624401,"sku":"ZBG-MOTS-10","price":99.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1039\/8718\/3953\/files\/IMG-4568.png?v=1779825949","url":"https:\/\/zurichbiogenix.com\/products\/mots-c-10mg","provider":"Zürich BioGenix","version":"1.0","type":"link"}