{"title":"Longevity","description":"","products":[{"product_id":"mots-c-10mg","title":"MOTS-C · 10mg","description":"\u003cp\u003e\u003cstrong\u003eMOTS-C\u003c\/strong\u003e is a 16-amino acid mitochondrial-derived peptide (MDP) encoded within the 12S rRNA region of the mitochondrial genome. It acts as a metabolic regulator that translocates to the nucleus under metabolic stress, where it activates AMPK and the FOXO pathway to improve insulin sensitivity, fatty acid oxidation, and skeletal muscle glucose uptake. MOTS-C has been studied in the context of exercise mimetics, longevity signalling, age-related metabolic decline, and mitochondrial biology.\u003c\/p\u003e\u003cp\u003eSynthesised and lyophilised in Zürich to \u0026gt;99% HPLC purity. Lot-traceable with full COA available upon request.\u003c\/p\u003e\u003cdetails\u003e\u003csummary\u003e\u003cstrong\u003eTechnical Specifications\u003c\/strong\u003e\u003c\/summary\u003e\u003ctable\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eChemical Name\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eMOTS-C (Mitochondrial ORF of 12S rRNA type-C)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eCAS Number\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e1627580-64-6\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eMolecular Formula\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eC101H152N28O22S2\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eMolecular Weight\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e2174.53 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eSequence\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eMet-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg (16 AA)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003ePurity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u0026gt;99% (HPLC-UV)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eForm\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eLyophilised Powder\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eStorage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e-20C, protect from light and moisture\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eReconstitution\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eBacteriostatic water or sterile saline\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e\u003c\/details\u003e\u003cdetails\u003e\u003csummary\u003e\u003cstrong\u003eResearch \u0026amp; Literature\u003c\/strong\u003e\u003c\/summary\u003e\u003cp\u003eMOTS-C was first characterised by Lee et al. (2015) in Cell Metabolism as a novel mitochondria-derived peptide encoded by the 12S rRNA region of the mitochondrial genome. Research has demonstrated its role in regulating insulin sensitivity, skeletal muscle glucose uptake, and adipogenesis through AMPK activation and FOXO pathway modulation. Studies in aged mice showed that systemic MOTS-C administration restored youthful metabolic homeostasis and improved exercise capacity, suggesting a role in longevity signalling.\u003c\/p\u003e\u003c\/details\u003e\u003cp\u003e\u003cem\u003eFor research purposes only. Not for human consumption. Supplied in accordance with EU Regulation (EC) No 1907\/2006 (REACH) for research and analytical use.\u003c\/em\u003e\u003c\/p\u003e","brand":"Zürich BioGenix","offers":[{"title":"Default","offer_id":53670369624401,"sku":"ZBG-MOTS-10","price":99.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1039\/8718\/3953\/files\/IMG-4568.png?v=1779825949"},{"product_id":"mots-c-40mg","title":"MOTS-C · 40mg (6-Week Supply)","description":"\u003cp\u003e\u003cstrong\u003eMOTS-C\u003c\/strong\u003e is a 16-amino acid mitochondrial-derived peptide (MDP) encoded within the 12S rRNA region of the mitochondrial genome. It acts as a metabolic regulator that translocates to the nucleus under metabolic stress, where it activates AMPK and the FOXO pathway to improve insulin sensitivity, fatty acid oxidation, and skeletal muscle glucose uptake. MOTS-C has been studied in the context of exercise mimetics, longevity signalling, age-related metabolic decline, and mitochondrial biology. This 40mg format provides an extended research supply.\u003c\/p\u003e\u003cp\u003eSynthesised and lyophilised in Zürich to \u0026gt;99% HPLC purity. Lot-traceable with full COA available upon request.\u003c\/p\u003e\u003cp\u003e\u003cem\u003eFor research purposes only. Not for human consumption. Supplied in accordance with EU Regulation (EC) No 1907\/2006 (REACH) for research and analytical use.\u003c\/em\u003e\u003c\/p\u003e","brand":"Zürich BioGenix","offers":[{"title":"Default","offer_id":53670369657169,"sku":"ZBG-MOTS-40","price":219.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1039\/8718\/3953\/files\/IMG-4569.png?v=1779826043"},{"product_id":"nad-plus-100mg","title":"NAD+ · 100mg","description":"\u003cp\u003e\u003cstrong\u003eNAD+ (Nicotinamide Adenine Dinucleotide)\u003c\/strong\u003e is an essential coenzyme present in all living cells, central to mitochondrial oxidative phosphorylation, DNA repair via PARP enzymes, and sirtuin-mediated epigenetic regulation. NAD+ levels decline significantly with age, and restoration has been extensively studied in the context of mitochondrial biogenesis, cognitive function, metabolic health, and longevity signalling pathways including the SIRT1\/AMPK axis.\u003c\/p\u003e\u003cp\u003eSynthesised and lyophilised in Zürich to \u0026gt;99% HPLC purity. Lot-traceable with full COA available upon request.\u003c\/p\u003e\u003cp\u003e\u003cem\u003eFor research purposes only. Not for human consumption. Supplied in accordance with EU Regulation (EC) No 1907\/2006 (REACH) for research and analytical use.\u003c\/em\u003e\u003c\/p\u003e","brand":"Zürich BioGenix","offers":[{"title":"Default","offer_id":53670369788241,"sku":"ZBG-NAD-100","price":69.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1039\/8718\/3953\/files\/IMG-4564.png?v=1779825186"},{"product_id":"epithalon-100mg-lyophilized-powder-synthetic-tetrapeptide-telomerase-activator","title":"Epithalon · 50mg","description":"\u003cp\u003e\u003cstrong\u003eEpithalon (Epitalon)\u003c\/strong\u003e is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from the thymus-produced polypeptide epithalamin. It is a potent telomerase activator, studied for its capacity to elongate telomeres in somatic cells, regulate the expression of genes associated with ageing, and restore circadian rhythm via pineal modulation. 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